Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

Enhanced HDL Functionality in Small HDL Species Produced Upon Remodeling of HDL by Reconstituted HDL, CSL112

RATIONALE CSL112, human apolipoprotein A-I (apoA-I) reconstituted with phosphatidylcholine, is known to cause a dramatic rise in small high-density lipoprotein (HDL). OBJECTIVE To explore the mechanisms by which the formation of small HDL particles is induced by CSL112. METHODS AND RESULTS Infusion of CSL112 into humans caused elevation of 2 small diameter HDL fractions and 1 large diameter...

It’s Time to Reassess the High-Density Lipoprotein (HDL) Hypothesis: CSL112, a Novel Promising Reconstituted HDL Formulation

C linical intervention studies have provided clear evidence that low-density lipoproteins are causally involved in the development of atherosclerosis. In contrast, data for highdensity lipoproteins (HDLs) are still inconclusive. A number of antiatherogenic properties have been ascribed to HDL, but the hypothesis that HDL is causally related to cardiovascular disease has been challenged seriousl...

HDL Cholesterol Story Is Dead: Long Live HDL!

It is a great irony that the earliest discovered lipoprotein is also the least well understood. In 1929, Michel Machebouef at the Pasteur Institute in Paris, using salt precipitation techniques, isolated a lipoprotein particle from horse serum composed predominantly of an a-globulin (59%), which we now know to be high-density lipoprotein (HDL) (1). Epidemiological studies in the 1970s, includin...

HDL remodeling during the acute phase response.

OBJECTIVE The purpose of this study was to examine the interactive action of serum amyloid A (SAA), group IIA secretory phospholipase A(2) (sPLA(2)-IIA), and cholesteryl ester transfer protein (CETP) on HDL remodeling and cholesterol efflux during the acute phase (AP) response elicited in humans after cardiac surgery. METHODS AND RESULTS Plasma was collected from patients before (pre-AP), 24 ...

HDL Function: Redefining the HDL Hypothesis for the 21 Century